Cytoskeleton, Inc. has been a reliable source of protein purification services in the areas of recombinant and native source proteins. Emphasizing on high purity and biological activity which enables the proteins to be used in many applications including diagnostic kits, pre-clinical drug development programs, early compound screening in primary HTS projects, and in ELISA formats. Cytoskeleton also have extensive experience in gene design and expression with an eye to produce the correct orientation and solubility for particular applications. Many purifications use the unique skills and expertise in cytoskeletal and signal transductions proteins. Using this combined knowledge we have produced many functional assays for kinesins (e.g., Eg5, CenPE, MKLP2), myosins (e.g., cardiac, smooth, skeletal, and non-muscle isoforms, sarcomere assys), small G-proteins (e.g., Rho, Arf, Ral families), tubulins (e.g., tumor, plant, and fungal origins), tubulin binding proteins (e.g., tau and MAPs) and actin binding proteins (e.g., cofilin, profiling, gelsolin), many of them are multi-protein assays that might have protein complexes of 3 or more subunits e.g., a soluble sarcomere format and the Arp2/3 complex based assay.

A particular speciality of Cytoskeleton's design formats is the ability to rapidly create lyophilized formulations in appropriate daily use or weekly use amounts. This enables HTS use and reproducible daily performance. Other experience in antibody and ELISA technology and protein synthesis complements the cytoskeletal and signal transduction focus. 

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Available Products:

CS-MH03   CS-MYS03   CS-MYS04   CS-MYS05